CELLULAR IMMUNITY ABNORMALITIES IN PATIENTS WITH RHEUMATOID ARTHRITIS
- VernacularTitle:类风湿关节炎患者细胞免疫功能研究
- Author:
Feng HUANG
;
Xinghua CAI
;
Guiying SHI
;
Xiangmei CHEN
;
Qingli CHENG
;
Ke DONG
;
Chenggui LIU
;
Yan LI
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis Lymphocyte subpopulations Interleukin 2 Interleukin 2 receptor Natural killer
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the cellular immunity abnormalities of patients with rheumatoid arthritis(RA), peripheral blood lymphocytes subpopulations, interleukin 2 (IL-2) production and natural killer (NK) cell activity were determined in 9 patients with RA. The results showed that there were a remarkable decrease in NK cell activity and poor response to IL-2 stimlulation. IL-2 production and.the expression of membrane-bound IL-2 receptor were increased in RA patients. The percentage of T4 positive cells and the ratio of T4/T8 were also increased in patients with RA. The results indicate that there are severe cellular immunity abnormalities in patients with RA.