Inhibition of Pulmonary Surfactant Function by Endotoxic Rat Plasma and Its Mechanisms
- VernacularTitle:内毒素血症大鼠血浆对肺泡表面活性物质功能的抑制及其机理
- Author:
Shaohua LI
;
Jinshan ZHANG
- Publication Type:Journal Article
- Keywords:
pulmonary surfactant;
endotoxin;
film balance;
plasma proteins;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The inhibition of bronchoalveolar surfactant function by endotoxic rat plasma was compared with that by normal rat plasma with M-8601 film balance. The results showed that endotoxic rat plasma significantly inhibited surfactant function of bronchoalveolar lavage (BAL). In the same protein concentration, the inhibition effects caused by endotoxic rat plasma were comparable with those by normal rat plasma. There were no changes of the inhibition effects after incubation of BAL with either endotoxic or normal plasma at 37℃ for 30min. These results suggest that the inhibition of surfactant function by the leakage of plasma in endotoxic lung injury is mainly due to protein components.
