The Effect of Lymphocyte Chalone on Bone Marrow Transplantation in Mice
- VernacularTitle:初步纯化的淋巴细胞抑素对小鼠骨髓移植效果的影响
- Author:
Yi GENG
;
Zhiguang MAI
;
Zhenhai DING
;
Jin ZHANG
- Publication Type:Journal Article
- Keywords:
lymphocyte chalone;
purification;
bone marrow transplantation
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Lymphocyte chalone was partially purified by ultrafiltration and chromatography on Sephadex G75. Its inhibitory effect on proliferation of T, B lymphocyte was demonstrated by [3H]-TdR incorporation method. In mouse bone marrow transplantation model, the treatment with lymphocyte chalone in vivo and in vitro was found to significantly improve the 30 d survival rate and prolong mean survival time, suggesting that it has an inhibitory effect on acute GVHD and is beneficial to H-2 incompatible bone marrow transplantation in mice.
