EFFECTS OF DIFFERENT DRUGS ON THE GENERATION OF ACTIVE OXYGEN IN POLYMORPHONEUCLEAR LEUKOCYTES ( PMN_s ) FROM RATS
- VernacularTitle:不同药物对大鼠多形核白细胞活性氧生成的影响
- Author:
Yongjie WU
;
Xinfang LI
- Publication Type:Journal Article
- Keywords:
Indomethacin;
BW-755C;
Calcium channel blocker;
Prostaglandin;
Polymorphoneuclear leukocytes;
Active oxygen
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
By the method of chemiluminescence, it was showed that BW-755C strongly inhibited the generation of active oxygen in PMNs stimulated by f-MLP, A23187 or opsonized zymosan A, while the inhibitory effect of indomethacin was quite weaker, Nifidipine, diltiazem and verapamil inhibited the generation of active oxygen in PMNs stimulated by A23187 at low concentration, but they did not block intracel-lular calcium ion increase stimulated by A23187. PGE1 was shown in to be a selective inhibitor of f-MLP-induced active oxygen production PMNs.
