EFFECT OF THREE TYPES OF CHELATING AGENTS ON EXCRETION AND DISTRIBUTION OF MERCURY
- VernacularTitle:三种类型螯合剂对汞在体内分布和排泄影响
- Author:
Zhengqin TAO
;
Zhenjia CHEN
;
Xueming YAN
- Publication Type:Journal Article
- Keywords:
Chelating agent;
203HgCl2;
Excretion;
Distribution
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
After the mice had been injected im203HgCl2 185 kBq/mouse, they were injected ip with chelating agents. There were 15 chelating agents of 3 types,of which the effect of eliminate mercury of pyridoxine derivative, benzenesul-fonate cysteine and sodium dimercaptosuccinate ( DMS-Na) were better than the others. The urine excretion of 208Hg was increased and the ratio were 4.6,11.5 and 22 respectively in comparison with the control group.The minimum 203Hg content in organs of mice was in the DMS-Na group,the next was the benzenesulfonate cysteine group,but there no significant difference between these 2groups.
