EFFECTS OF L-THP ON HEMODYNAMICS IN ANAESTHETIZED RATS
- VernacularTitle:左旋四氢巴马汀对麻醉大鼠血流动力学影响
- Author:
Shaoguang WU
;
Xiaolan LI
;
Shilan REN
;
Guoju ZHAO
- Publication Type:Journal Article
- Keywords:
L-tetrahydropalmatine;
hemodynamics
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Hemodynamic study of L-THP in anaesthetized rats showed that 6 mg/kg iv decreased only blood pressure (BP) significantly, and decreased left ventricular pressure ( LVP ) temporarily. At the dose of 18 mg/kg, L-THP lowered the BP, LVP, ? ( dP/dt ) max, ( dP/dt ) P-1 and HR. But the degrees o?diminutions of BP were greater than that of cardiac contractility. The inhibitory percentage of L-THP on DAP was greater than that of SAP. In addition, the extent of decrease of DAP was shown dose dependently. The results suggest that L-THP reduces the peripheral vessel resistance, and it inhibits the cardiac contractibility in high dosage.
