DETOXIFICATION MECHANISM OF METHIONINE AND VITAMIN E IN SELENIUM TOXICITY IN RATS
- VernacularTitle:蛋氨酸和维生素E对大鼠硒中毒的解毒机制
- Author:
Xiaoyan ZHANG
;
Guangqi YANG
;
Luzhen GU
- Publication Type:Journal Article
- Keywords:
Se detoxification vitamin E DL-methionine trimethylselenonium ion
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The weaning male Wistar rats were fed diets with 0.2, 2.0 and 5.0 ppm as Na2SeO4 respectively for 7 weeks. On each Se level, rats were divided into groups with or without supplementation of vitamin E and DL-methi-onine (VE-Met) and possible metabolic interactions of VE-Met to dietary Se at different levels in relation to the detoxification mechanism were ob- served. The results showed that only rats in unsupplemented, 5 ppm Se-diet group exhibited distinct toxic manifestations, and supplementation of VE-Met to this group gave effective protection against the toxic action. In the supplemented group Se content of blood, liver, kidneys and skeletal muscle of the experimental animals was decreased, while the excretory rate of urinary trimethylselenonium ion was increased to a level of 33% in contrast to 22% in the unsupplemented group (P
