EFFECT OF ANORDRIN AND ITS ANALOGUE ON THE UTERINE ENDOMETRIAL STRUCTURE IN MICE
- VernacularTitle:抗孕-53及其类似物对小鼠子宫内膜结构的影响
- Author:
Shuxiang LI
;
Yao YUAN
- Publication Type:Journal Article
- Keywords:
Anordrin;
SIPPR-113;
Estrogen;
Endometrium
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In this paper attempt has been made to observe the effect of Anordrin and its analogue SIPPR-113 on the morphological characters of uterine endometrium in mice implantation period and after castration. 100 mice were used in two experiments. The first experiment was performed in mice after mating, it included 5 groups as follows: control, estradial, progesterone, Anordrin and SIPPR-113 groups. The mice were treated with least doses (2-4mg/kg) which can prevent implantation on dayl-2 after mating. The animals were killed on the 5th day of pregnancy. The second, experiment contained also 5 groups: mature female mice were treated with 1/4-1/2 of above doses on the 25-26th day and were killed on the 29th day after castration. The uterine endometrium was embedded with paraffin and Epon812, histological sections and semi-thin sections (1ftm thick) and ultra-thin sections were made. They were observed under light microscope and electron microscope (Hitachi-600). Similar results were obtained in the two series of experiments. The endometrium had grown obviously and the numbers of glands and of cell's mitosis were increased, edema was indicated in stroma, as well as secretory function of glands was prevented period of implantation. Some lysosomes and lipid drops were found in the glandular cells and micro-filaments were observed in stromal cells under electron microscope. The effect of SIPPR-113 were similar to Anordrin, their anti-implantation action may be related to their estrogen and anti-progestrone action. Acknowledgement: This work was supported by WHO Special Programme in Human Reproduction.
