Inhibition of Proliferation of Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D_3 and Retinoic Acid
- VernacularTitle:1,25(OH)_2D_3和维甲酸对巨核白血病细胞的增殖抑制作用
- Author:
Tao CHENG
;
Fang YAN
;
Jinghua WAN
;
Jianlin YIN
- Publication Type:Journal Article
- Keywords:
1,25-dihydroxyvitamin D3;
retinoic acid;
megakaryoblastic leukemia cells;
proliferation inhibition
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment.
