EFFECT OF L-STEPHANINE ON APOM ORPHINE-INDUCED ROTATIONAL BEHAVIOUR IN RATS
- VernacularTitle:左旋千金藤碱对大鼠旋转模型的作用
- Author:
Guoqing LIU
;
Zhiqing MA
;
Xiaonan JIN
;
Feng YU
- Publication Type:Journal Article
- Keywords:
L-stephanine;
Circling model;
DA receptor blocker
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Rats receiving unilateral nigral injection of 6 OHDA resulted in distinct reduction of DA (-88% ) , DOPAC(-80%) and HVA(-60%) in striatum of lesioned side, and the contents of 5HT and 5HIAA remained almost constant in comparison with that of contralateral striatum, suggesting selective lesion of nigrostriatal dopaminer-gic pathway induced by 6OHDA. Following 6OHDA lesion the rats exhibited circling behaviour after APO challenge. 1-Stephaniae ( 1-STP ) significantly antagonizied the action of APO in circling model in dose-dependent manner. Our results indicate that 1-STP possesses the ability to block DA receptor of central nervous system.
