STUDIES ON THE ANTAGONISM OF 8601 AGAINST EXPERI-MENTAL EPILEPSY IN MICE
- VernacularTitle:顺-3,4-二氯-?-氯代桂皮酰另丁胺的抗实验性癫痫作用及其机制的研究
- Author:
Cheng TAO
;
Bo ZHENG
;
Xiangfang ZHOU
;
Shuyu WANG
- Publication Type:Journal Article
- Keywords:
Cis-3 , 4-dichloro-?-chloro-cinnamoyl-sec. -butyla-mine;
Experimental epilepsy;
5HT;
Glutamic acid;
Aspartic acid
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Cis-3, 4-dichloro -a-chloro-cinnamoyl-sec.-butylamine (8601), a new compound of cinnamamides, has potent antagonistic effect on experimental epilepsy. 8601 is significantly more effective against MES in mice than Antiepilepsirine. It has also been found effective against convulsion induced by icv. injection of sodium glu-tamate and zinc sulfate.The mechanisms of anti-MES of 8601 is related to content of 5 HT in the whole brain of mice. Increased cerebral 5 HT with L-tyrosine potentiated the effect of anti-MES of 8601,while the opposite was obtained using reserpine or pCPA which decreased the concentration of cerebral 5 HT. The increase of cerebral 5 HT is correlated with the effect of anti-MES of 8601 with a correlation coefficient of 0.926 ( P
