STUDY OF ANTI-INFLAMMATORY EFFECTS OF FERULOFEN AND ITS MECHANISMS
- VernacularTitle:阿魏洛芬的抗炎作用及其机理研究
- Author:
Chengguang YU
;
Chuanbing YU
;
Mingmin ZHAO
- Publication Type:Journal Article
- Keywords:
Ferulofen;
Rat carrageenin pleurisy;
Peritoneal macrophage;
Cell activation;
H_2O_2 release;
NSAIDs
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Anti- inflmmatory effects of ferulofen(FL)and its mechanisms were studied. In the rat carrageenin pleurisy, FL produced a dose-related reduction of exudate volume, protein contents and leucocyte numbers in the exudate. FL also reduced activity of ?-glucuronidase in the exudate only in higher dose 3 h after carrageenin. These results suggest that FL has a marked anti-inflammatory action and its mechanisms may be similar to indomethacin. Ia vitro, FL caused a dose-dependent inhibition of hydrogen peroxide release from rat peritioneal macrophages ( M0 ) stimulated by opsonized zymosan. It suggested that its anti-inflammatory mechanisms may also relate to inhibitting cell activation. ?-receptor agonist ( Isoproterenol, ISO), in a ineffective dose, synergized with FL in inhibitting M H2O2 release and the synergic mechanism remains to be established.
