EFFECTS OF FUROSEMIDE ON ACTION POTENTIAL AND CONTRACTILE FORCE OF ISOLATED TOAD ATRlAL MYOCARDIUM
- VernacularTitle:呋喃苯胺酸对蟾蜍心肌电与机械活动的影响
- Author:
Weiming FU
;
Chengbiao LU
;
Shaoru LI
- Publication Type:Journal Article
- Keywords:
Furosemide;
Verapamil;
Atrial myocardium;
Action potential;
Contractile force
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Using floating microelectrode, the effects of furosemide on action potential and contractile force were studied in isolated toad atrial myocardium. Furosemide increased the force of contraction of toad right atrial myocardium, amplitude and dV/dtmax of action potential, and prolonged action potential duration at 50% repolari-zation (APD50), but the APD25, APD90 and sinus cycle length ( SCL) were not influenced. The positive intropic effect of furosemide could be blocked by Verapamil. These results indicated that furosemide could promote the Ca++ inward current.
