THE EFFECT OF SOPHORIDINE ON THE MYOCARDIAL FUNCTIONS OF NORMAL RAT HEARTS IN VIVO
- VernacularTitle:槐定碱对正常大鼠心脏功能的影响
- Author:
Suqin YANG
;
Xingzhong JIN
;
Ruisong LI
- Publication Type:Journal Article
- Keywords:
Sophoridine;
Adrenaline;
Heart function test;
Myocardial volume of oxygen index ( MVO_2I )
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The LVdP/dtmax, LVSP, AP and Vmax of the rat hearts in vivo were increased by Sophoridine ( 2 mg/kg, given to rats iv ) by 19.5, 13.1, 14.8 and 28.2% respectively. Such a positive inotropic effect lasted for more than 5 min and was statistically significant. Adrenaline (0.16 ?g/kg, iv ) could also increase the LVdP/dtmax and Vmax of the heart obviously and this action was not stronger than Sri after uses of drugs except at 0.5 min and vanished more quickly. There was an increment of MVO2I because of the increased arterial pressure within 3 min after use of Sri, which was much less than adrenaline. The present results show Sri strengthened the cardial force for longer time and affected the arterial pressure and MVO2I less than adrenaline in the rat hearts in vivo.
