STUDIES ON THE TOXICITY OF TOTAL GLUCOSIDES OF PAEONY
- VernacularTitle:白芍总甙的毒性研究
- Author:
Jun LI
;
Yanfeng LI
;
Aiwu ZHOU
- Publication Type:Journal Article
- Keywords:
TGP;
LD_(50);
Acute toxicity;
Long-term toxicity
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
2500mg/kg ( ig ) gave no any toxic symptom nor death. In long-term toxicity test, 50, 1000 and 2000mg/kg?d-1 ig on 30~90 consecutive days to rats and 280 and 560mg/kg?d-1 ig on 90 consecutive days to dogs respectively, revealed no significant toxicity in general physical signs, body weight, appearance. behavious, routine urine test, routine blood test, liver and kidney function tests, histological examinations of important organs, blood biochemistry tests and electrocardiogram, except that the platelet numbers of both animals increased.
