EFFECT ON INTRACELLUIAR LIPID METABOLISM BY VERAPAMIL AND GLUCOSYLATED LDL
- VernacularTitle:维拉帕米和糖基化对细胞内胆固醇含量的影响
- Author:
Naifeng LIU
;
Dingan LOU
- Publication Type:Journal Article
- Keywords:
Calcium antagonists;
Verapamil;
Glucosylation;
Low density lipoprotein;
Cholesterol
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to investigate the effects of calcium antagonists and glucosylated LDL on intracellular lipid metabolism . The human serum LDL was isolated by density gradient ultracentri-fugation and glucosylated by incubation with glucose. The content of intracellular cholsterol was determined by enzymatic method which is simple, convenient and satisfactory. It was found that the contents of cholesterol in cultured human fibroblasts incubated with verapamil and(or)glucosylated LDL were higher than those incubat- ed with control LDL or without verapamil. The results suggested that calcium antagonists and glucosylation of LDL might affect in-tracellular lipid metabolism and play a role in atherosclerosis.
