EFFECTS OF BERBAMINE HCL ON ISOLATED WORKING HEART OF GUINEA PIG
- VernacularTitle:盐酸小檗胺对豚鼠离体工作心脏的作用
- Author:
Baofeng YANG
;
Baiyan LI
;
Xichen WU
;
Wenhan LI
- Publication Type:Journal Article
- Keywords:
Working heart;
Berbamine;
Left ventricular pressure;
Arrhythmia
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The isolated working heart of guinea pig perfused with Tyrode's solution could work normally for at least 60 min. It was shown that berbamine ( BA ) could depress the function of isolated working heart of guinea pig in dose-dependent manner. BA 3 mol/L could decrease the left ventricular pressure, aortic pressure, -dP/dtmax, aortic blood flow and coronary blood flow, and increase left ventricular end-diastolic pressure. BA 100 mol/L could result in the ventricular asystole, however, no obvious influence the contraction of atrium.It was also demonstrated that BA could antagonise the arrhythmias induced by the adrenaline in isolated working heart of guinea Pig.
