Analysis of Clinical, Biochemical and Pathologic Factors According to the Response to Initial Steroid Therapy in Active Crohn's Disease.
- Author:
Jae Geun HYUN
1
;
Jae J KIM
;
Young Ho KIM
;
Byeong Hoon AHN
;
Jae Hyuk DO
;
Min Kyu RYU
;
Jae Kwon JANG
;
Jee Eun KIM
;
Dong Il PARK
;
Poong Lyul RHEE
;
Kwang Cheol KOH
;
Seung Woon PAIK
;
Jong Chul RHEE
;
Kyoo Wan CHOI
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jjkim@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Serum albumin;
Initial steroid response;
Active Crohn's disease
- MeSH:
Crohn Disease*;
Diagnosis;
Female;
Granuloma;
Humans;
Inflammation;
Male;
Medical Records;
Recurrence;
Retrospective Studies;
Serum Albumin
- From:Korean Journal of Gastrointestinal Endoscopy
2001;22(6):406-410
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory factor of the response to initial steroid therapy in active Crohn's disease patients. METHODS: The medical records of 32 patients with active Crohn's disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. RESULTS: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68.8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. CONCLUSIONS: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group.
