The Effect of Human Placental Lipopolysaccharide and Protein-free Serum on Hematopoietic Reconstitution in Normal and Irradiated Mice
- VernacularTitle:人胎盘脂多糖和胎盘无蛋白血清对正常和受照射小鼠造血功能的影响
- Author:
Minghua ZHANG
- Publication Type:Journal Article
- Keywords:
placental extracts;
placenta] lipopolysaccbaride;
placental protein-free serum;
radiation injuries;
hematopoiesis;
radiation protection
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
In the present study, the contents of pluripotential stem cell (CFU-S) and granulopoietic progenitor (CFU-GM) in bone marrow, and morphological characteristics of hematopoietic tissue were tested at different time after injection of human placental lipopolysaccharide or protein-free serum in normal and ?-ray-irradiated mice. Our study showed that both of these placental extracts could not only stimulate hematopoiesis in normal mice but also accelerate hematopoietic reconstitution, and increase the survival of mice exposed to 7.5 Gy. From these results, we consider that administration of these extracts might be useful in accelerating hematopoietic recovery in patients with chemotherapy or radiotherapy induced neutropenia.
