Effects of TRH on Lipid Peroxidation in Spinal Cord Injury in Rat
- VernacularTitle:TRH对大鼠脊髓损伤脂质过氧化的影响
- Author:
Fengchi HE
- Publication Type:Journal Article
- Keywords:
thyrotropin releasing hormone;
spinal cord injury;
lipid peroxidation;
free radicals;
superoxide dismutase
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
The effects of thyrotropin releasing hormone (TRH) on lipid peroxidation in spinal cord injury in rats were studied. It was found that TRH (0.2 mg/kg, 0.6mg/kg, 2.0mg/kg bolus, followed by the same doses/h over 4 h, iv) could inhibit lipid peroxidation of the injuried spinal cord, decrease malondialdehyde (MDA)production and significantly increase superoxide dismutase (SOD) activity in a dose-dependent manner. The results indicate that the antioxidant effects of TRH are the result of increase of SOD activity. TRH might be an effective free radical scavenger.
