MECHANISM OF IMMUNOMODULATORY ACTIONS OF TOTAL GLUCOSIDES OF PAEONY IN MICE
- VernacularTitle:白芍总甙调节小鼠免疫功能的机理
- Author:
Xingwang WANG
;
Wei WEI
;
Mingzhu CHEN
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
Total glucosides of paeony;
Th/Ts cell ratio;
Immunomodulatory action;
Indirect immunofluorescence;
Cyclophosphamide
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Mechanism of Immunomodulatory actions of total glucosides of paeony ( TGP ) was studied by McAb indirect immunofluorescence. TGP 5 mg/( kg?d ) ip for 8d suppressed DTH, that was enhanced by cyclophosphamide( Cy), and decreased L3T4+/Lyt-2+ 〔 (Th/i)/(Ts /c) 〕 cell ratio in ICR mice .TGP 5 mg/ ( kg?d ) ip for 5d enhanced DTH that was suppressed by Cy, and increased the L3T4+/Lyt-2 + cell ratio in ICR mice. The same dose of TGP ip for 5d promoted the hemolysin production of spleen cells, that was suppressed by Cy, increased the L3T4+/Lyt-2 + cell ratio in BLAB/c mice. The results suggest that immunomodulatory actions of TGP might be brought about by altering Th/Ts cell ratio.
