DOSE-EFFECT RELATIONSHIP OF DMPS ON ACUTE POISONING CAUSED BY SCD
- VernacularTitle:二巯基丙磺酸钠对杀虫单急性中毒解毒的量效关系
- Author:
Zhongqiu LU
;
Zhikang CHEN
- Publication Type:Journal Article
- Keywords:
DMPS;
SCD;
Poisoning;
Dose-effect relationship,Drug;
Tranqilizing agents;
Neuromusclar blocking agents;
Convulsions
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In peroneal nerve-anterior tibialis muscle preparations of uretbane anesthetized rabbits, sodium ammonium dimethyl-2 -( propano-1 , 3 - dithiosulfonate ) monohydrate ( SCD ) 7 .5mg/kg iv depressed the antogenous respiration completely and the indirectly elicited twitch tension completely finally. Sodium 2, 3 - dimercaptopropane- 1-sulfonate ( DMPS ) 7、 10mg/kg iv,respectively completely antagonized the respiratory depression and the neuromuscle block, DMPS (2.4、 3.4、 4.9mg/kg, iv ) could antagonize these toxic effects partly. DMPS (62.5mg/kg ,iv)could antagonize the toxic symptom induced by SCD(7.5 mg/kg, iv)in rabbits. At dose level higher than 12.5mg/kg of SCD, this toxin caused tremor and tonic convulsion. e Wfound DMPS (62.5 mg/kg, iv ) combined with diazepam ( 5mg/kg, iv ) has antidotal effects on acute poisoning caused by SCD in rabbits.
