EFFECTS OF THE COMBINATION OF ASPIRIN AND VERAPAMIL ON PLATELET AGGREGATION AND THROMBOGENESIS
- VernacularTitle:阿斯匹林与维拉帕米并用对血小板聚集和血栓形成的影响
- Author:
Erdan DONG
;
Shan SHI
- Publication Type:Journal Article
- Keywords:
Aspirin;
Verapamil;
Platelet aggregation;
Carotid artery thrombosis;
Pulmanary thrombosis;
Synergism
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of Verapamil ( Ver ) . Aspirin ( ASA ) and ASA+ Ver on platelet aggregation and generation of thrombosis were studied. ASA and Ver inhibited rabbit platelet aggregation in vitro and rat platelet aggregation in vivo induced by ADP, also prolonged the occlusion time of thrombosis that was induced electrically in the carotid artery of the rat, and reduced the death rate resulted from pulmonary thrombosis that was induced with inducer composed of collagen and epinephrine iv in mice. The effects of Ver and ASA were markedly increased when combined, meanwhile all showed good dose-dependant manner.
