THE INFLUENCE OF CIMETIDINE ON THE PHARMACOKINETICS OF FTORAFUR IN RATS
- VernacularTitle:西咪替丁对大鼠体内呋喃氟脲嘧啶药代动力学的影响
- Author:
Yunsheng GAO
;
Yaoqin ZHENG
;
Yuyun ZHU
- Publication Type:Journal Article
- Keywords:
Ftorafur;
Cimetidine;
Pharmacokinetics;
Drug interaction;
Reversed-phase high performance liquid chromatography
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The influence of cimetidine on the pharmacokinetics of ftorafur ( FT-207 ) in 9 rats after intragastric administration were investigated with cross-over design. The concentration of ftorafur in serum was determined by reversed-phase HPLC. Its curve of concentration vs time was fit to one compartment opened model. The serum concentrations and areas under the curve ( AUC ) vs time were increased when cimetidine orally administered daily for 5d or single dose. The peak of serum and AUC of ftorafur were increased by 21 .0%(P
