Effect of Burn Injury on the Contractile and Relaxation function of Isolated Perfusion Heart in Guinea-pigs
- VernacularTitle:烧伤对豚鼠离体灌流心脏收缩及舒张功能的影响
- Author:
Jing LI
- Publication Type:Journal Article
- Keywords:
burns;
myocardial contractility;
myocardial oxygen consumption
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
By mean of the isolated perfused working heart model, the changes of myocardial contractile and relaxation functions, ventricular cell action potentials, myocardial oxygen and glucose consumptions etc. were observed at 1st,3rd, 8th and 24th h after burn injury in the guinea-pigs inflictedly III degree burn injury on 35% TBA. The results indicate that. 1 ) The contractile and relaxation functions go through a time course of 'normal-decrease-recover', i.e. the cardiac functions show a normal level within 1 h after burn injury. Then they are depressed gradually,and to the lowest at 8th h or so, after burn injury. The cardiac functions recover partly at 24th h after burn injury. It suggests that there is a repaired mechanism by itself in heart of the burn animal; 2 ) The depression of myocardial contractile and relaxation functions are related with depression of the oxygen consumption rather than reduce of intaking in nutrients; 3) the influencing factors of burn injury on the coronary flow and electrical activity of myocardial cells could be removed easily by the perfusate. It shows that these effects may be result from the extracardiac neurohumoral factors.
