THE ROLE OF THROMBOXANE AND ITS INHIBITOR ANISODAMINE IN BURN SHOCK
- VernacularTitle:血栓素及其抑制剂氢溴酸山莨菪硷在烧伤休克治疗中的作用
- Author:
Yuesheng HUANG
;
Ao LI
;
Zongcheng YANG
- Publication Type:Journal Article
- Keywords:
Burn shock TXA2 Burn
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The serial changes in thromboxane (TXA2) prostacyclin(PGI2),circulatory platelet aggregate ratio (CPAR),platelet count,blood viscosity,myocardial enzyme spectrum,cortisol and epinephrine were determined in 42 severely burnt patients randomly divided into two groups.The findings demonstrated that in the control group,both TXA2 and TXA2/PGI2 ratio increased significantly during the early postburn stage.Myocardial enzyme spectrum,blood viscosity,cortisol and epinephrine also increased markedly.However,levels of the above parameters in the anisodamine-treated group were significantly lower than in the control following the infusion of anisodamine.On the contrary,CPAR and platelet count in the treated group increased and were significantly higher than those in the control.Moreover,TXA2 was closely correlated with CPAR,platelet count,blood viscosity and myocardial enzyme spectrum (P
