Effect of Dexamethasone on Plasma Atrial Natriuretic Peptide Levels during Hemorrhagic Shock in Dogs
- VernacularTitle:地塞米松对犬失血性休克血浆心钠素的影响
- Author:
Weimin WANG
- Publication Type:Journal Article
- Keywords:
atrial natriuretic peptide;
dexamethasone;
shock, hemorrhagic;
dog
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Ten healthy mongrel dogs of either sex were divided into two groups: Dex-treated group (n=6) and NS-treated group (n=4). The dogs were attacked with hemorrhagic shock by bleeding via left femoral artery. Dex-treated group was given Dexamethasone (5mg/kg) at mean arterial pressure (MAP) of 13.3 kPa. NS-treated was given placebo of 0.9% Nad solution. The atrial natriuretic peptide (ANP) was determined by radioimmunoassay. Plasma level of ANP decreased progressively 5 h after shock. There was a significant positive correlation between the extent of reduction of MAP and that of plasma ANP (r=0.871203, n=16, P
