An Observation of Experimental Autoimmune Uveitis in Guinea Pigs by Light and Electron Microscope
- VernacularTitle:实验性自身免疫性葡萄膜视网膜炎的光镜及电镜观察
- Author:
Hui WANG
- Publication Type:Journal Article
- Keywords:
S antigen;
immunologic diseases;
uveitis;
diseae models, animal
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The soluble antigen was isolated from pig retinal extract by precipitation with ammonium sulfate followed by molecular sieve. 50 ?g S antigen with equal volume complete Freund's adjuvant was injected into double hind foodpads of guinea pigs. Two weeks later, experimental autoimmune uveitis developed. Its pathologic feature is that a great number of lymphocytes infiltrated into chroid which was thickened gradually from anterior to posterior. Inflammatory variation was relative to disease phase. Ultrastructure pathology was characterized by swelling and necrosis in the inner and outer segments of photorecepter cells. This result suggests that S antigen has significant effect on inducing experimental autoimmune uveitis and the outer layer of retina is the sensitive target organ of S antigen.
