Effect of Soman on the Nicotinic Acetylcholine Receptor
- VernacularTitle:梭曼、沙林和VX对N-乙酰胆碱受体的作用
- Author:
Qingwu MAO
- Publication Type:Journal Article
- Keywords:
nicotinic acetylcholine receptor;
VX;
soman;
satin;
mice;
rats
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The highly specific ligand of the N-acetylcholine receptor (N-AChR) was used to determine the effect of scman, sarin and VX on N-AChR of the diaphragm, and extensor digitorum longus muscle of the mouse and rat The effects of the three anticholinesterase agents on N-AChR were different Sarin didn't directly act on N-AChR and cause a change in the number of N-AChR VX decreased the binding site of the receptor through directly binding N-AChR The ID50 was 0.054 mg/kg mouse. Soman increased the binding sites, e.g. 1-1.5 LD50 soman increased the N-AChR of mouse diaphragm for 25% of the control. The increase in N-AChR was up to a highest peak 0.5 h after poisoning and continued for 96 h. The receptor number was still 22% higher than that of the control on the fourth day after soman poisoning in the rat Soman mainly increased the number of extrasynaptic N-AChR, leading to the enhancement of sensitivity of cholinergic effector to ACh. This simulates the sensibilization resulting from denervation. These findings are of significance in probing the receptor mechanisms and treatment of the soman poisoning.
