The Changes of Rat Thyroid Gland C Cells in Acute Intestinal Radiation Sickness (AIRS)
- VernacularTitle:大鼠甲状腺C细胞在肠型放射病中的变化
- Author:
Xiaolin DENG
;
Wenqin CAI
- Publication Type:Journal Article
- Keywords:
thyroid gland;
calcitoninj acute intestinal radiation sickness
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The rats were exposed to 20Gy of X-ray one time systemically to imitate the model of AIRS. By using immunocytochemistry, immunoelectromicroscopy and microspectrophotometry (MSP) technique , the changes of rat thyroid gland C cells in AIRS were investigated. The results show that, the changes of C cells could be divided into two phases. In the first phase (the first 24 h after irradiation) , no obvious morphological change could be observed, whereas the concentration of serum calcium (CSC) dropped remarkably. It seems that the synthesis and secretion of calcilonin (CT) within C cells might increase during this period. The second phase is from 24th h to 72th h after irradiation, the TA (total absorbance) measured by MSP reduced. and the ultrastructural pictures showed progressive destructive changes. All these findings suggest that: The C cells of rat thyroid gland, as a kind of APUD system cell, is no doubt involved in the AIRS pathological changes. The possible pathogenic mechanism was briefly discussed.
