EFFECTS OF PINGYANGMYCIN, ADRIAMYCIN AND THYMOSIN ON THE RELEASE OF IL-2 IN VITRO
- VernacularTitle:抗瘤药和胸腺素对小鼠脾细胞TL—2产生的影响
- Author:
Jian LI
;
Yuanshan SHEN
- Publication Type:Journal Article
- Keywords:
IL-2, PYM, ADM, Thymosin.
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The antineoplastic drugs pingyangmycin ( PYM ) and adriamycin ( ADM ) and biological response modifier thymosin were tested for the effects on concanavalin A ( Con-A ) induced interleukin-2 ( IL-2 ) production by MTT colorimetric assay. When the drug was added to splenocytes of BALB/c mice in the presence of suboptimal dose of Con-A for 24h ,PYM increased IL-2 release over a wide range of doses, and this effect was achieved when using less than 0.01mg/L PYM. However, 10mg/L PYM inhibited IL-2 activity in the supernatant of cultures. ADM was able to enhance the production of IL-2, and thymosin enhance production of IL-2 too.When PYM or ADM applied with thymosin, the additive effects were shown. The activity of IL-2 was increased significantly.
