NEGATIVE INOTROPIC EFFECT OF ZINC SULFATE IN ISOLATED GUINEA PIGS ATRIA
- VernacularTitle:硫酸锌对豚鼠心房肌的负性变力作用
- Author:
Xin MA
;
Xiaoguang LI
- Publication Type:Journal Article
- Keywords:
Zinc sulfate;
Heart atrium;
Heart muscles contraction
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Zinc sulfate 0.1mmol/L inhibited the frequency dependent positive staircase phenomenon on isolated guinea pig atria. Ten min after adding zinc sulfate 0.1 mmol/L, the contractility of the left atrium decreased. The needed concentration of epinephrine inducing automaticity was increased and the functional refractory period(FRP) was prolonged from 192?5 ms to 247?4 ms ( P
