CARDIOVASCULAR EFFECTS OF SOPHORAMINE
- VernacularTitle:槐胺碱的心血管作用
- Author:
Xiaowei CUI
;
Gaohong FENG
- Publication Type:Journal Article
- Keywords:
Sophoramine;
Hypotensive action;
Sympathetic ganglia;
Positive inotropic action;
Vasodilation;
Arrhythmia
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Sophoramine ( Sa ) is an alkaloid from sophora alopecuroides. Linn., in anesthetize animals ( cat, rat and rabbit), intravenous adminstra-tion of Sa reduced rapidly and markly the arterial blood pressure. The mechanism of hypotension effect of Sa is mainly attributable to its sympathetic ganglionic blocking and direct vasodilatation. Experiment on the isolated hearts of guinea pig revealed that Sa produced negative chronotropic and positive inotropic action, and increased coronary flow simultaneously.In a study of experimental arrhythmia in animals,we observed that Sa could reduce the arrhythmia induced by aconitine in rats and decreased the incidence of ventricular fibrillation induced by chloroform in mice.
