EFFECTS OF TYPHA ANGUSTIFOCIA L AND ITS EXTRACTS ON ARACHIDONIC ACID INDUCED PLATELET AGGREGATION IN RABBITS
- VernacularTitle:蒲黄及其提取物对花生四烯酸诱导血小板聚集功能的影响
- Author:
Fengming LIU
;
Shan SHI
;
Zengxi LI
- Publication Type:Journal Article
- Keywords:
Typha angustifocia L;
Flavone;
Organic acid;
Polysaccharide;
Platelet aggregation;
Platelet aggregation slope;
Arachidonic acid
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Typha angustifocia L(TA ) and its extracts: total flavones ( FT ) , organic acids ( OT ) , and poly saccharide ( PT ) inhibited platelet-aggregation induced by arachidonic acid in rabbits significantly and dose-dependend in vitro. The IC50-m of TA, FT, OT and PT for maximum aggregation % was 9.3, 3.0, 12.1, and 6.5g/L PRP and IC50-s for aggregating slope was 10.8, 4.3, 17.7 and 15.3 g/L PRP respectively. The ratio of IC50-m/IC50-s was TA 1 : 1.2, FT 1 : 1.4, OT 1 : 1.5, and PT I : 2.4 respectively. FT and OT also showed inhibition to platelet aggregation exvivo. The results proved that flavones may be the principal effective ingredient of Typha angustifocia L on platelet aggregation and responsible for the difference the drug effects on maximum aggregation % and aggregation slope between.
