ANTI-INFLAMMATORY EFFECT OF TOTAL SAPONINS OF ROOT OF PANAX NOTOGINSENG ( TSPR )
- VernacularTitle:三七根总皂甙的抗炎作用及其作用机制
- Author:
Baoheng ZHANG
;
Wenjun PAN
;
Huanran TAN
- Publication Type:Journal Article
- Keywords:
Total of root of Panax notoginseng;
Hydrocortisone;
Inflammation;
Infiltration;
Granuloma;
Croton oil;
Acetic acid
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The anti-inflammatory effect of total saponins of Panax notoginseng (TSPR ) were reported. After intramuscular injection of TSPR (200 mg/kg, rats and mice) and hydrocortisone ( 300mg/kg, rats ; 200mg/ kg, mice) the ear inflammation induced by croton oil decreased. Thirty minutes after intramuscular injection of TSPR ( 200mg/kg ) and hydrocortisone ( 200mg/kg ) in normal mice, the inflammation induced by acetici ( ip) shown by the infiltration of Even's blue decreased significantly.It is suggested antiinflammatory effect of TSPR was not related to the hypothalamic adrenal system.In chronic inflammatory experiments, TSPR as well as hydrocortisone could inhibit the proliferation of granuloma by the implantation of cotton pellet in rats and mice with inhibitory rates of 27.6% ( P
