THE SUPPRESSIVE EFFECTS OF CYCLOSPORIN A ON IMMUNE FUNCTION IN MICE
- VernacularTitle:国产环孢素A对小鼠免疫功能的抑制作用
- Author:
Aihua XU
;
Zhibin LIN
- Publication Type:Journal Article
- Keywords:
Cyclosporin A;
PFC;
Hemolysin;
DCH;
Cardiac grafts;
Clearance rate of charcoal particles;
Bone marrow cells
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The suppressive effects of cyclosporin A ( CsA ) made in China on immune function were studied in mice. CsA ( 25 and 50 mg/kg ig for 4 d ) caused a significant decrease of spleen plaque forming cell ( PFC ) in mice. At the dose of 25, 50 and 100 mg/kg ig for 4 d, CsA inhibited the production of hemolysin in a dose-dependent manner in mice immunized with SRBC. CsA ( 25, 50 and 100 mg/kg ig for 10d ) also markedly inhibited the delayed cutaneous hypersensitivity ( DCH ) induced by DNCB in mice. CsA 50 mg/kg ig for 14d prolongated survival time of cardiac grafts. The treatment with CsA could not reduce the clearance rate of iv charcoal particles as well as bone marrow cells in mice. There was no significant difference of immu-nosuppressive effect on PFC response between China-made CsA and Sandoz-made CsA
