THE INHIBITON OF CHLORPROMAZINE ON ACTIVATION OF TYROSINE HYDROXYLASE BY PHORBOL DIBUTYRATE
- VernacularTitle:氯丙嗪对佛波二丁酯致活酪氨酸羟化酶的抑制作用
- Author:
Maoyin WANG
- Publication Type:Journal Article
- Keywords:
chlorpromazine;
Tyrosine hydroxylase;
Phorbol dibutyrate;
Protein kinase C;
Phosphorylation
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Basing on the previous report, experiments proved that chlorpro-mazine decresed DOPA formation in superior cervical ganglion ( SCG ) for 50%, and formation from PDB for 60%. The work ruled out the possibilities of decrease of DOPA synthesis from the effect on N-or M-cholinergic receptor or from the influence on DOPA decarboxylase activity. So the decrease of DOPA formation was due to inhibition of protein kinase C blocking phosphorylation of tyrosine hydroxylase.
