Double Drug Interaction between Propafenone and Digoxin
- VernacularTitle:普罗帕酮与地高辛的相互作用
- Author:
Gaolin LIU
- Publication Type:Journal Article
- Keywords:
propafenone;
digoxin;
interaction;
pharmacokinetics;
pharmacodynamics
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The double drug interaction between propafenone (PF) and digoxin (D) was investigated in twelve healthy volunteers. The subjects were randomly divided into two subgroups and each group received PF, D, PF plus D at different administration plan, respectively. The serum D concentration (SDC) and plasma PF concentration (PPFC) were measured by fluorescence polarization immunoas-say (FPIA) and high performance liquid chromatography (HPLC), respectively. The concentration -time data of PF were inputted into an IBM/PC/XT microcomputer. The MCPKP - automatic pharmacokinetic program (worked out by Xia WJ) was employed for selection of the optimal compartment model and calculation of the pharmacokinetic parameters using weighted nonlinear least square regression.The results of this study showed that SDC (mean?SD) rose from 0.64?0.14 ng/ml to 0.83?0.17 ng/ml (mean increase 31.57?20.81%, P0.05), but there was great interindivi-dual variability. Although no normal man had serious adverse effects from the PF plus D interaction, in patients receiving D and PF simultaneously, the SDC should be monitored and the dosage of D readjusted if there is evidence of toxicity.
