The States of HBV in Human Primary Hepatoceilular Carcinoma and Tumor-adjacent Tissues: A Comparative Study
- VernacularTitle:人原发性肝癌和癌旁组织HBV存在状态的对照研究
- Author:
Zhaorui LIAN
- Publication Type:Journal Article
- Keywords:
HBV;
primary hepatocellular carcinoma;
PHC
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The present paper reports on the study of HBV states in human primary hepatocellular carcinoma (PHC) and tumor-adjacent tissues. The results showed that in 11/12 PHC (91.5%) and 9/12 tumor-adjacent tissues (75%) there were integrated forms of HBV DNA. The amount of HBV integrated in PHC was higher than that in tumor-adjacent tissues, indicating a clonal selection for liver cells containing integrated HBV during the malignant transformation of PHC. In two tumor-adjacent tissues only free HBV was found, while in the corresponding PHCs there was integrated HBV DNA. This suggests that integration had taken place in the process of carcinogenesis of PHC. It was also observed in this study that four patients had putatively defective HBV in their liver cells which could be replicated but not be secreted into serum. The possible role of HBV in the carcinogenesis of PHC is discussed
