Inhibitory Effect of Meperidine on Tracheal Vascular Permeability Increased by Hot Air Injury in Rat
- VernacularTitle:哌替啶抑制热空气对大鼠气管烧伤机理的探讨
- Author:
Lezhi ZHANG
;
Yingqu LI
- Publication Type:Journal Article
- Keywords:
burns, inhalation/DT;
meperidine/PD;
naloxone/PD;
malondi-ildehyde;
superoxide dismutase;
capillary peraeability/DE
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Colorimeter detection of Evas Blue in formamide extract of rat tracheal tissue is used as an indication of increased vascular permeability induced by introduction of 115 degrees C air into the rat trachea, followed by a dose (20mg/kg) of meperidine given. The increases of tracheal vascular permeability (TVP) and malondialdehyde (MDA) level induced by hot air injury (HAI) are markedly inhibited. The decrease of superoxide dismutase (SOD) activity induced by HAI is raised. The inhibitory effect of meperidine (MIE) on TVP is not antagonized by naloxone. It is implied that the opiate receptor sensitive to naloxone is not involved in the MIE on TVP. The decrease of tracheal MDA content, increase of tracheal SOD activity raising the ability of scavengering oxygen free radicals and reducing the formation of other active oxygen, inhibit lipid peroxidation. These antioxidative effects may be one aspect of the mechanism of the inhibiory effect of meperidine on TVP.
