EFFECTS OF SURAZEPAM ON THE CONTRACTILE FUNCTION OF UTERINE SMOOTH MUSCLE
- VernacularTitle:舒乐安定对子宫平滑肌收缩性能的影响
- Author:
Shaoyu CHENG
;
Weiji LI
;
Jiaqing QIAN
- Publication Type:Journal Article
- Keywords:
Surazepam;
Nifedipine;
Oxytocin;
Cervix uteri
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Surazepam ( Sur ) is a benzodiazepine derivative. Sur ( 0.2~0.27m-mol/L ) inhibited the contraction of isolated cervices uteri of rats and human beings induced by oxytocin and Ca2+ after high K+ concentration depolarization Sur ( 3.5~ 4 mg/kg ) iv could also inhibit the spontaneous contraction of uterus of rabbit in situ. The cumulative dose-response curves for Sur and CaCl2 exhibited non-competition.Both Sur and nifedipine markedly inhibited extracellular and intra-cellular Ca2+ dependent contraction induced by oxytocin.
