EFFECTS OF SRI63-441 ON ENDOTOXIN AND PAF INDUCED LUNG INJURY
- VernacularTitle:SRI63—441对内毒素和血小板激活因子致肺损伤作用的影响
- Author:
Ziqiang DING
;
Shaohua LI
;
Xia FEI
- Publication Type:Journal Article
- Keywords:
Endotoxin;
Platelet-activating factor;
Receptor antagonist;
Lung injury;
Bronchoalveolar lavage
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A bolus injection of endotoxin and platelet activating factor ( PAF ) via external jugular vein in rats resulted in severe pulmonary edema, accompanied by significant increase in extravascular lung water volume, bronchoalveolar lavage fluid ( BALF ) protein concentration, BALF cell counts and polymorphonuclearcyte percentage. PAF receptor antagonist SRI63-441 showed partial protective effects on endotoxin and PAF induced lung edema and BALF cytological changes.
