Histopathological and Ultrastructural Changes in the Lung with Blast Injury
- VernacularTitle:肺冲击伤的病理组织学和超微结构变化
- Author:
Zhengguo WANG
- Publication Type:Journal Article
- Keywords:
blast injury;
lung/UL;
pinocytosis;
free radicals
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Lung samples are taken from 14 dogs, 12 guinea pigs & 20 rats injured by 200 g TNT explosion after 6 - 8 h, observed with light microscope & electron microscope (LM & EM). Animals dying within several min after injury show bleeding from the mouth and nose and dyspnea. By naked eyes: widespread hemorrhage and edema in the lungs are seen. By LMs interstitial and alveolar hemorrhage and edema, some ruptured alveoli, margination of neutrophils in the venulesi various degrees of neutrophilic infiltration in the alveolar septa are obrerved. By EM; large amount of RBC. edematous fluid, neutrophils, monocytes, deprivated type II pneumocytes, fibrin exudate and surfactant in mesh or packed form in alveolar lumen, some type II cells are swollen and vacuolized or disrupted, reduction or evacuation of lamina bodies, even degenerated. Most of the endothelial cells" are markedly swollen. There are significant pinocytosis and myeiln figure formation in some cell cytoplasm. In a cross section of a capillary only one CEC is swollen while the others are normal. No abnormal change in the alveolar septa is seen. In the early stage aggregation of RBC and WBC in capillary lumen, neutrophilic degranulation, migrination and dissolution of the neutrophilic cell membrane may be related to release of free radicals and destruction of endothelia. Aggregation, margination and degranulation of platelets are probably related to release of thromboxane A2.
