EFFECT OF 3, 6-DIMETHAMIDODIBENZOPYRIODONIUM CITRATE ( IHC-65 ) ON PLATELET FUNCTION AND cAMP LEVEL IN RABBITS
- VernacularTitle:3,6—[二甲氨基]—二苯骈碘杂六环枸橼酸盐对家兔血小板功能cAMP水平的影响
- Author:
Jiliang WU
;
Peilun QIU
;
Shuying CHEN
- Publication Type:Journal Article
- Keywords:
3 ,6-dimethamidodibenzopyriodonium citrate ( IHC - 65 );
Platelet aggregation;
Serotonin;
Cylic AMP
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
IHC-65 was found to be a potent inhibitor of platelet function . It inhibited platelet aggregation induced by threshold concentration of ADP, arachidonic acid and collagen with dose-dependent manner in vitro, and at 96?mol/L, AIR ( aggregation inhibition rate,) were 71.56, 66.93 and 68.47% respectively. IHC-65 inhibited platelet serotonin release induced by collagen,and at 96 ?mol/L, release inhibition rate was 82.97%. IHC-65 did not influence cAMP level in platelet significantly. It is concluded that IHC-65 inhibited platelet aggregation and its action mechanism may be related to inhibition of serotonin release and to antagonizing Ca ++ .
