EXPRESSION OF PRE-S2 PROTEIN OF HBV IN LIVER TISSUECONPARED WITH OTHER HBV ANTIGENS
- VernacularTitle:乙型肝炎时肝内前S_2蛋白的表达
- Author:
Shimin ZHANG
;
Chunwu ZHU
;
Fenglian HAN
;
Hongfei ZHANG
;
Shuxiu CHENG
;
Shouchun YANG
;
Yun CHENG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus Pre-S2 protein
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Pre-S2 protein in 78 samples of liver from patients with various types of hepatitis B was determined by immunohistochemical method.45 out of 78 samples (57.69%) were positive for pre-S2.The location and expression patterns of pre-S2 were similar to those of HBsAg,i.e.,pre-S2 was found in cytoplasm of hepatocytes,epithelial cells of bile ducts,and hepatocellular carcinoma cells,etc,Four different patterns diffuse,inclusion,submembranous,and membranous type were demonstrated.The membranous expression of pre-S2 was often associated with activity of liver diseases.The positive rate of pre-S2 was significantly higher in HBcAg positive group than HBcAg negative group.It seems that pre-S2 protein of HBV may be a replicative marker of HBV.
