The Damage Effect of Phospholipase A_2 on Cultured Pulmonary Artery Endo thelial Cells
- VernacularTitle:磷脂酶A_2对培养的小牛肺动脉内皮细胞的损伤及氯喹的保护作用
- Author:
Qi WANG
- Publication Type:Journal Article
- Keywords:
phospholipase A2;
pulmonary endothelial cells;
chloroquine
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The damage effect of phospholipase A2 on cultured calf pulmonary artery endothelial cells and the protective effect of chloroquine were investigated. The results showed: the cellular membrane permeability was increased by phospholipase A2( PLA2),the numbers and the extent of lanthanum particles in cytoplasm were positive correlation with increased concentration and prolonged reacting time of PLA2 and lactate dehydrogenase release rate, angiotensin-converting enzyme activity and malondialde-hyde content were increased significantly compared with normal control group, PLA2+chloroquine group and chloroquine group. Chloroquine could protect the cells damaged by PLA2.
