Synthesis and Antithrombotic Effect of CI-930
- VernacularTitle:咪苯甲嗪酮的合成及其抗血栓作用
- Author:
Weiqin WAN
- Publication Type:Journal Article
- Keywords:
CI-930;
synthesis;
phase transfer reaction;
antithrombotic effect
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
A novel cardiotonic CJ-930 was successfully designed and synthesized with a new synthetic route. The method and reactive condition on acylating, hydrolytic and condensating reaction were also improved.In addition to convenience of operation, a new synthetic route showed also the advantage over Sircar's method on the raising of total yield 26% to 36%.This compound significantly inhibited the in vitro aggregation of rabbit platelet induced by arachidonic acid, U46619, collagen, ADP and platelet activating factor(PAF). In rabbit or rat platelet, CI-930 depressed the synthesis of thromboxane A.
