Effects of Furazolidone on Reserpine-Induced Gastric Ulcers and on Brain Monoamine Contents in Rats
- VernacularTitle:呋喃唑酮对利血平诱发的大鼠胃溃疡和脑内单胺递质的影响
- Author:
Ming YIN
- Publication Type:Journal Article
- Keywords:
furazolidone;
gastric ulcer;
monoamines;
reserpine;
pargyline;
clonidine;
animal model
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of furazolidone(Fur), pargyline(Parg) and clonidine(Clo) on reserpine(Res)-induced gastric ulcers and on brain monoamine contents were studied in male Sprague-Dawley rats. It was found that: (1) Fur almost completely and both Parg and Clo significantly prevented the formation of Res-induced gastric ulcers; (2) Fur prevented the exhaustion of brain monoamines induced by Res and(3) Parg increased NA and 5-HT contents but Clo did not. These results suggest that the inhibitory effect of Fur on brain MAO plays an important role in its anti-gastric ulcer mechanism.
