An Experimental Study of Pathogenesis of Acute Lung Injury Induced by Complement Activation in Conscious Goat, Roles of Leukocytes and Prostaglandins
- VernacularTitle:白细胞和前列腺素在活化补体导致的急性肺损伤中的作用
- Author:
Shengxiang GUO
- Publication Type:Journal Article
- Keywords:
lung diseases/PP;
lung/IN;
complement/PH;
leukopenia;
thromboxanes
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The roles of leukocytes and prostaglandins in mediating alterations of pulmonary hemodynainics and lung fluid exchange after intravenous autologous zymo-san-activated plasma (ZAP) challenge is investigated in 14 conscious goats with chronic lung-lymph-fistula. In the control group, ZAP infusion causes the mean pulmonary arterial pressure (Ppa) markedly elevate, lung lymph flow (QI) and the lymph-to-plasma protein concentration ratio (L/P) increase. There is a significant correlation between Ppa and the content of plasma TXB2. In antiPMNs serum-induced leukopenia group, the extent of increment in Pp a is not as obvious as the normal goats, and no marked change is observed in QI, L/P and content of TXB2. These results indicate: l.TXA2 releases from leukocytes may affect lung fluid exchange during ZAP infusion; 2. leukocytes may play an important role in ZAP-induced lung injury.
