ANTAGONISM OF ANTIEPILEPSIRINE AGAINST AMYGDALA-KINDLING IN RAT
- VernacularTitle:抗痫灵对大鼠杏仁核点燃效应的拮抗作用
- Author:
Huiqiu WU
;
Qianxian PING
;
Xiaoming JIA
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Kindling model;
Basolateral amygdaloid;
Afterdischarge;
Antiepilepsirine;
Sodium valproate
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of antiepilepsirine, a derivative of piperine, on the rat amygdala kindled seizures was studied. An average of daily consecutive 15 stimulations was needed to reach the first stage 5 seizures, at which the rats showed behavioral convulsions and electroencephalogra-phic abnormalities. Antiepilepsirine ip 2 h before stimulation at the doses that did not show obvious sedation suppressed the stage 5 seizures with the ED50 of 84.7mg/kg and exhibited insignificant shortening of afterdischarge duration. Sodium valproate effectively protected against stage 5 seizures and shortened the afterdischarge duration. Present data suggest the chronic antiepileptic property of antiepilepsirine in rat amygdala kindling model.
